塚田 稔

研究概要

社会に生きる知の創成―コミュニケーションと認知による知の創成―

人間の行動決定やコミュニケーションによる知の創成は、人間の生き方や、芸術文化、教育、経済、産業の根幹をなすこれほど重要な機能はない。この機能は脳に内在し、変化する外界との相互作用によって、能動的に獲得するものである。この知の創成の機能を明らかにするためには、脳の構成単位である神経細胞の性質を解析するだけでなく複雑システムとしてのメカニズムを明らかにする必要がある。本研究はボトムアップとトップダウンの相互作用に注目し、その記憶・記憶メカニズムを理論と実験の共同研究によって明らかにしようとするもので、新しい実験科学と理論科学の学際領域の研究に貢献するばかりでなく知能ロボットの開発をはじめ人間社会のイノベーションに貢献する。
具体的には海馬と皮質の記憶・学習システムに注目し，コミュニケーションと認知による知の創成に関する学習・記憶の情報表現を理論と実験の学際的アプローチによって明らかにする。特に学習ルール、記憶の情報表現の脳内メカニズムに重点を置く。

原著論文

• Integration of Hetero Inputs to Guinea Pig Auditory Cortex Established by Fear Conditioning” , Yoshinori Ide, Muneyoshi Takahashi, Johan Lauwereyns, Minoru Tsukada and Takeshi Aihara , Advances in Cognitive Neurodynamics III., 2012, The Netherlands: Springer,, pp.765 - 772
• “Influence of the Endogenous Acetylcholine on STDP Induction” Advances in Cognitive Neurodynamics III. , Takeshi Aihara, Eriko Sugisaki, Yasuhiro Fukushima and Minoru Tsukada, The Amsterdam,, 2012, Netherlands: Springer,, pp.387 - 392
• Fear Conditioning Induces Guinea Pig Auditory Cortex Activation by Foot Shock Alone , Ide,Y, Takahashi M, Lauwereyns Y, Sandner G, Tsukada M and Aihara T, Cognitive Neurodynamics, 2012, Vol.6, pp1 - 10
• The theta cycle and spike timing during fixation in rat hippocampal CA1., Takahashi M, Isomura Y, Sakurai Y, Tsukada M, Lauwereyns J, In: Omori T, Tsuda I, Yamaguchi Y (Eds.) , Advances in Cognitive Neurodynamics III. Amsterdam, , 2012, The Netherlands: Springer.
• Memory information representation in the　hippocampus. , Tsukada M, In: Omori T, Tsuda I, Yamaguchi Y (Eds.), , Advances in Cognitive Neurodynamics III., 2012, Amsterdam, The Netherlands: Springer
• Fukushima Y, Isomura Y, Yamaguti Y, Kuroda S, Tsuda I, Tsukada M, Inhibitory network dependency in Cantor coding., T, Tsuda I, Yamaguchi Y (Eds.), In: Omori , Advances in Cognitive Neurodynamics III., 2012, Amsterdam, The Netherlands: Springer.
• Context and the renewal of conditioned taste aversion: The role of rat dorsal hippocampus examined by electrolytic lesion. , Fujiwara H, Sawa K, Takahashi M, Lauwereyns J, Tsukada M, Aihara T, , Cognitive Neurodynamics, 2012, 6, 399 - 407
• Optical imaging of plastic changes induced by fear conditioning in the auditory cortex. , Ide Y, Miyazaki T, Lauwereyns J, Sandner G, Tsukada M, Aihara T,, Cognitive Neurodynamics, 2012, 6, 1 - 10
• Cholinergic modulation on spike timing-dependent plasticity in hippocampal CA1 network. , Sugisaki E, Fukushima Y, Tsukada M, Aihara T. , Neuroscience. Vol 192, 2011, pp.91 - 101
• A mathematical model for Cantor coding in the hippocampus. , Yamaguti Y, Kuroda S, Fukushima Y, Tsukada M, Tsuda I, , Neural Networks, 2011, 24, 45 - 53
• A context-sensitive mechanism inhippocampal CA1 networks. , Tsukada M, Fukushima Y , Bulletin of Mathematical Biology, 2011, 73, 417 - 435
• Spatiotemporal characteristics of synaptic EPSP summation on the dendritic trees of hippocampal CA1 pyramidal neurons as revealed by laser uncaging stimulation. , Yoneyama M. Fukushima Y. Tsukada M. Aihara T , Cognitive Neurodynamics, 2011, 5, 333 - 342
• Neural substrate of sound duration discrimination during an auditory sequence in the guinea pig primary auditory cortex, Okazaki S, Kanoh S, Tsukada M, Oka K, Hear Res, 2010/01, 259(1-2), 107 - 16
• Prototype seizure activity driven by mature hippocampal fast-spiking interneurons., Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Ninomiya T, Tsukada M, Yanagawa Y, Fukai T, Takada M , J. of Neuroscience, 2010, 30, 13679 - 13689
• レーザーアンケージング刺激による海馬CA1錐体細胞の樹状突起上のEPSPの時間･空間加重特性の解析　, 米山, 福島, 小島, 塚田, 日本神経回路学会誌　, 2010
• Iterated function systems in the hippocampal CA1, Kuroda S, Fukushima Y, Yamaguti Y, Tsukada M, Tsuda I, Cogn Neurodyn, 2009/09, 3(3), 205 - 22
• Dual Synaptic Plasticity in the Hippocampus: Hebbian and Spatiotemporal Learning Dynamics, Kaneki K, Araki O, Tsukada M, Conitive Neurodynamics, 2009/06, 3(2), 153 - 63
• Behavioral state-dependent episodic representations in rat CA1 neuronal activity during spatial alternation, Takahashi M, Lauwereyns J, Sakurai Y, Tsukada M, Cogn Neurodyn, 2009/06, 3(2), 165 - 75
• Behavioral state-dependent episodic representations in hippocampal CA1 neuronal activity during spatial alternation. , Takahashi M, Lauwereyns J, Sakurai Y, Tsukada M., Cognitive Neurodynamics. , 2009, 3, , 165 - 175
• A code for spatial alternation during fixation in rat hippocampal CA1 neurons., akahashi M, Lauwereyns J, Sakurai Y, Tsukada M., J. Neurophysiol , 2009, 102, , 556 - 567
• Iterated Function Systems in the Hippocampal CA1. , Kuroda S, Fukushima Y, Yamaguti Y, Tsukada M, Tsuda I, Cogn Neurodyn, 2009, 3, , 205 - 222
• 脳と芸術　, 塚田稔, 日本神経回路学会誌 , 2009, 16(2), 64 - 76
• Reward prediction based on stimulus categorization in primate lateral prefrontal cortex. , Pan X, Sawa K, Tsuda I, Tsukada M, Sakagami M., Nature Neuroscience, 2008, 11(6): , 703 - 712
• Neural correlates of true memory, false memory, and deception. , Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T., Cerebral Cortex , 2008, 18(12), 2811 - 2819
• Coding mechanisms in hippocampal networks for learning and memory., Fukushima Y, Tsukada M, Tsuda I, Yamaguti Y, Kuroda S., Lecture notes for INNS-NNN08 symposia., 2008
• Spatial clustering property and its self-similarity in membrance potentials of hippocampal CA1 pyramidal neurons, Fukushima Y, Tsukada M, Tsuda I, Yamaguti Y, Kuroda S, Cognitive Neurodynamics , 2007, 1, 305 - 316
• The relation between spike-timing dependent plasticity and Ca2+ dynamics in the hippocampal CA1 network, Aihara T, Abiru Y, Yamazaki Y, Watanabe H, Fukushima Y, Tsukada M, Neuroscience , 2007, 145, 80 - 87
• Reproducing Bursting Interspike Interval Statistics of the Gustatory Cortex, Fujiwara K, Fujiwara H, Tsukada M, Aihara, K, BioSystems , 2007, 90, 442 - 448
• Interaction between the Spatio-Temporal Learning Rule (STLR) and Hebb type (HEBB) in single pyramidal cells in the hippocampal CA1 Area, Tsukada M, Yamazaki Y, Kojima H, Cognitive Neurodynamics , 2007, 1.2, 157 - 167
• Functional Differences between the Spatio-Temporal Learning Rule (STLR) and Hebb type (HEBB) in single pyramidal cells in the hippocampal CA1 Area, Tsukada M, Yamazaki Y, Lecture note in Computer Science, Springer , 2006, Volume 4232/2006, 72 - 81
• A model of the hippocampal-cortical memory system, Pan X, Tsukada M, Biolgical Cybernetics , 2006, 95. 2, 159 - 167
• Phase shift of subthreshold theta oscillation in hippocampal CA1 pyramidal cell embrane by excitatory synaptic inputs, Watanabe H, Aihara T, Tsukada M, Neuroscience , 2006, 140.4, 1189 - 1199
• Change detection and difference detection of tone duration scrimination, Okazaki S, Kanoh S, Takaura K, Tsukada M, Oka K, Neuroreport , 2006, 17.4, 395 - 399
• A spatio-temporal learning rule based on the physiological data of LTP induction in the hippocampal CA1 network, Tsukada M, Aihara T, Saito H, Kato H, Lecture Notes in Computer Science, Springer , 2006, Volume 1112/1996, 709 - 714
• Development of a system for patterned rapid photolysis and 2-photon confocal microscopy. November issue, Kojima H, Simburger E, Boucsein C, Maruo T, Tsukada M, Okabe S, Aertsen Ad, IEEE Circuit and Device (Leos) , 2006, 22.6, Nov-Dec, 66 - 74

著書

• 「脳の可塑性」　自己組織化ハンドブック, 塚田 稔, （株）エン・ティー・エス, 2009/05
• 芸術と脳観, 塚田稔，塚田信，ヤン・ローレンス, 玉川大学DTP, 2009
• The Chapter 6. Interaction between the Spatio-Temporal Learning Rule(non-Hebbian) and Hebbian in Single Cells: A cellular mechanism of reinforcement learning in the Book: Reinforcement Learning-Theory and Applications, Tsukada M, I-TECH Education and Publishing, 2008/01
• 自己組織化ハンドブック，4.2.1「脳の可塑性」　, 塚田稔, ㈱エヌ・ティー・エス, 2008
• Reinforcement Learning-Theory and Applications. , Tsukada M., The Chapter 6. Interaction between the Spatio-Temporal Learning Rule(non-Hebbian) and Hebbian in Single Cells, A cellular mechanism of reinforcement learning : I-TECH Education and Publishing, 2008
• Synaptic plasticity (essay). , Tsukada M., Encyclopedia of Neuroscience, Springer., 2008

国際会議

• T Kamijo, I Tsuda, Y Yamaguti, Y Fukushima, M Tsukada, T Aihara. , 口頭発表, Cantor coding for a spatio-temporal input sequence in the CA1. , The Society for Neuroscience, Neuroscience 2012,, New Orleans, 2012/10/13
• Y. Ide, M. Takahashi, J.M. Lauwereyns, M. Tsukada, and T. Aihara. , 口頭発表, Activation of Guinea Pig Auditory Cortex Induced by Foot Shock Alone after Fear Conditioning. , The Society for Neuroscience, Neuroscience 2011, , Washington DC, 2011/11/15
• E. Sugisaki, Y. Fukushima, M. Tsukada, T. Aihara. , 口頭発表, Acetylcholine modulation on STDPinCA1region of hippocampus. , The Society for Neuroscience, Neuroscience 2011, Washington DC, 2011/11/14
• M. Kondo, M. Tsukada, H. Sasaki, T. Aihara. , 口頭発表, Interaction of dendritic locations on STDP of hippocampal CA1 area using optical imaging. , 8th IBRO World Congress of neuroscience, IBRO2011, Florence, 2011/07/18
• E. Sugisaki, Y. Fukushima, M. Tsukada, T. Aihara. , 口頭発表, Modulation by acetylcholine of STDP in rat hippocampal CA1 network. , 8th IBRO World Congress of Neuroscience, IBRO2011, Florence, 2011/07/18
• Y. Ide, M. Takahashi, J. Lauwereyns, G. Sandner, M. Tsukada, and T. Aihara. , 口頭発表, The Influence of Fear Conditioning on Activation of Guinea Pig Auditory Cortex in the Absence of Sound. , 8th IBRO World Congress of Neuroscience, IBRO2011, Florence, 2011/07/16
• Y. Ide, M. Takahashi, J. Lauwereyns, M. Tsukada, and T. Aihara. , 口頭発表, Integration of Hetero Inputs to Guinea Pig Auditory Cortex Established by Fear Conditioning. , The 3rd International Conference on Cognitive Neurodynamics, ICCN2011, Niseko, Hokkaido , 2011/06/10
• Takeshi Aihara, Eriko Sugisaki, Yasuhiro Fukushima and Minoru Tsukada. , Influence of the endogenous acetylcholine on STDP induction. , The 3rd International Conference on Cognitive Neurodynamics, ICCN2011, Niseko, Hokkaido , 2011/06/10
• Tsukada M. , 招待講演, Memory Information Representation in the Hippocampus., ICCN2011, Niseko, Hokkaido , 2011/06/10
• Kuroda S, Fukushima Y, Yamaguchi Y, Tukada M, Tsuda I, 口頭発表, Emergence of Iterated Function Systems in the Hippocampal CA1. , ICCN’09, Hangzhou, China, 2009/11
• Tsukada M, Organiser & Chairman , 11thTamagawa Dynamic Brain Forum, DBF '09, Shizuoka, 2009/03
• Fukushima Y, Tsukada M, Tsuda I, Yamaguti Y, Kuroda S. , 口頭発表, Possibility of Cantor coding by spatial input patterns. , 15th International Conference on Neural Information Processing of the Asia-Pacific Neural Network Assembly (ICONIP-2008) , Auckland, New Zealand, 2008/11/25-2008/11/28
• Ide Y, Lauwereyns J, Tsukada M. , 口頭発表, Optical imaging of plastic changes induced by fear conditioning in the auditory cortex of guinea pig. , 15th International Conference on Neural Information Processing of the Asia-Pacific Neural Network Assembly (ICONIP-2008) , Auckland, New Zealand, 2008/11/25-2008/11/28
• Tsukada M, 招待講演, Coding mechanisms in hippocampal networks for learning and memory, 15th International Conference on Neural Information Processing of the Asia-Pacific Neural Network Assembly, APNNA, 2008/11
• Fukushima Y, Kiryu S, Tsukada M, Aihara T., 口頭発表, The effect of the proximal dendritic input on the information processing at the distal dendrite by means of back-propagating action potential in the hippocampal CA1 neuron. , Annual Meeting of the American Society for Neuroscience, Washington, DC, U.S.A., 2008
• Miyamoto A, Toujoh S, Sakai K, Katsumata S, Kojima H., 口頭発表, An analysis of synaptic transmission and its plasticity by glutamate receptor channel kinetics models and 2-photon laser photolysis. , 1st International Symposium, INNS-NNN 2008, Auckland, New Zealand, 2008
• Tsukada M, Fukushima Y, Tsuda I, Yamaguti Y, Kuroda S. , 口頭発表, Cantor coding mechanisms in hippocampal networks for learning and memory. , 1st International Symposium, INNS-NNN 2008, Auckland, New Zealand., 2008
• Tsukada M., 招待講演, Coding mechanisms in hippocampal networks for learning and memory. , 1st International Symposium, INNS-NNN 2008, Auckland, New Zealand., 2008
• Tsukada M, Organizer & Chairman/Mini-symposium , the 1st International Conference on Cognitive Neurodynamics, ICCN'07, 2007/11

国内会議

• 塚田稔, 口頭発表, 「脳に学ぶ絵画技術」 , 東京都美術館改修記念市民講座（日府展主催）, 2012/05/26
• 塚田稔, 基調講演, 「創造する脳」基調講演タイトル「美の創造への脳科学的アプローチ」 , NPO法人ニューロクリアティブ研究会セミナー, 2009/10/27

受賞

• ICCN国際会議：功績賞, 塚田稔, 2011
• The Excellent Service Award, APNNA, Tsukada M, 2007
• 電子情報通信学会フェロー称号授与, 塚田稔, 2005
• The Best Achievement Award, ICNONIP, Tsukada M, 2000
• 日本神経回路学会論文賞, 塚田稔, 1997

記事掲載／その他

• 「脳から考える美術の魅力と創造すること」, サイエンス・ウインドウ 2013 4-6号 , 科学技術振興機構 , 2013/03
• 「記憶力を今すぐUPした～い」, すイエんサー／NHK教育TV , 2010/01/19
• 「受験勉強記憶術」, 月刊「高１My Vision」／ベネッセ　 , 2009/09
• 「脳科学SP」, 宇宙GメンTAKUYA／ニッポン放送, 2009/06/23
• 「受け取る力」ヒトの感知メカニズム, 季刊「てら」／NTTコムウェア 掲載：39号, 2009/06
• 「脳科学SP」, 宇宙GメンTAKUYA／ニッポン放送 , 2009/05/19

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