彦坂 興秀

原著論文

• pyElectrode: An open-source tool using structural MRI for electrode positioning and neuron mapping. , Daye PM, Monosov I, Hikosaka O, Leopold DA, Optican LM , J Neurosci Methods , 2013, 213: , 123 - 131
• The primate ventral pallidum encodes expected reward value and regulates motor action. , Tachibana Y, Hikosaka O, Neuron , 2012, 76: , 826 - 837
• Robust representation of stable object values in the oculomotor basal ganglia. , Yasuda M, Yamamoto S, Hikosaka O, J Neurosci , 2012, 32: , 16917 - 16932
• What and where information in the caudate tail guides saccades to visual objects. , Yamamoto S, Monosov IE, Yasuda M, Hikosaka, O, J Neurosci , 2012, 32: , 11005 - 11016
• Regionally distinct processing of rewards and punishments by the primate ventromedial prefrontal cortex. , Monosov IE, Hikosaka O, J Neurosci , 2012, 32: , 10318 - 10330
• Learning to represent reward structure: a key to adapting to complex environments. , Nakahara H, Hikosaka O , Neurosci Res , 2012, 74: , 177 - 183
• Electrical Stimulation of the Primate Lateral Habenula Suppresses Saccadic Eye Movement through a Learning Mechanism. , Matsumoto M, Hikosaka O, PLoS One, 2011, 6:e26701
• Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. , Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O, J Neurosci , 2011, 31:, 11457 - 11471
• Initiation and inhibitory control of saccades with the progression of Parkinson's disease - Changes in three major drives converging on the superior colliculus. , Terao Y, Fukuda H, Yugeta A, Hikosaka O, Nomura Y, Segawa M, Hanajima R, Tsuji S, Ugawa Y , Neuropsychologia , 2011, 49:, 1794 - 1806
• Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons., Bromberg-Martin Ethan S, Matsumoto Masayuki, Hikosaka Okihide, Neuron, 2010, 67(1), 144 - 155
• Multiple timescales of memory in lateral habenula and dopamine neurons. , Bromberg-Martin ES, Matsumoto M, Nakahara H, Hikosaka O, Neuron , 2010, 67:, 499 - 510
• A pallidus-habenula-dopamine pathway signals inferred stimulus values. , Bromberg-Martin ES, Matsumoto M, Hong S, Hikosaka O, J Neurophysiol , 2010, 104:, 1068 - 1076
• Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease. , Yugeta A, Terao Y, Fukuda H, Hikosaka O, Yokochi F, Okiyama R, Taniguchi M, Takahashi H, Hamada I, Hanajima R, Ugawa Y, Neurology , 2010, 74:, 743 - 748
• Representation of negative motivational value in the primate lateral habenula, Matsumoto M, Hikosaka O, Nat Neurosci, 2009, 12, 77 - 84
• Two types of dopamine neuron distinctly convey positive and negative motivational signals. , Matsumoto M, Hikosaka O, Nature , 2009, 459:, 837 - 841
• Habenula: crossroad between the basal ganglia and the limbic system, Hikosaka O, Sesack SR, Lecourtier L, Shepard PD, J Neurosci , 2008, 28, 11825 - 11829
• New insights on the subcortical representation of reward, Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M, Curr Opin Neurobiol , 2008, 18, 203 - 208
• The globus pallidus sends reward-related signals to the lateral habenula, Hong S, Hikosaka O, Neuron, 2008, 60, 720 - 729
• Combining Modalities with Different Latencies for Optimal Motor Control., Bissmarck F, Nakahara H, Doya K, Hikosaka O, J Cogn Neurosci, 2008, 20, 1966 - 1979
• A neural correlate of motivational conflict in the superior colliculus of the macaque, Isoda M, Hikosaka O, J Neurophysiol , 2008, 100, 1332 - 1342
• Brain mechanisms for switching from automatic to controlled eye movements, Hikosaka O, Isoda M, Prog Brain Res, 2008, 171, 375 - 382
• Negative motivational control of saccadic eye movement by the lateral habenula, Matsumoto M, Hikosaka O, Prog Brain Res, 2008, 171, 399 - 402
• Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus, Nakamura K, Matsumoto M, Hikosaka O, J Neurosci, 2008, 28, 5331 - 5343
• Combining Modalities with Different Latencies for Optimal Motor Control. , Bissmarck F, Nakahara H, Doya K, Hikosaka O, J Cogn Neurosci , 2008, 20: , 1966 - 1979
• Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement. , Isoda M, Hikosaka O, J Neurosci , 2008, 28: , 7209 - 7218
• Switching from automatic to controlled action by monkey medial frontal cortex., Isoda M, Hikosaka O, Nat Neurosci, 2007/01, Jan 21
• Temporal development of asymmetric reward-induced bias in macaques. , Ding L, Hikosaka O, J Neurophysiol, 2007/01, 97(1), 57 - 61
• The role of the dorsal striatum in reward and decision-making, Balleine BW, Delgado MR, Hikosaka O, J Neurosci , 2007, 27, 8161 - 8165
• Basal Ganglia Mechanisms of Reward-oriented Eye Movement, Hikosaka O, Ann N Y Acad Sci , 2007, 1104, 229 - 249
• GABAergic output of the basal ganglia, Hikosaka O, Prog Brain Res, 2007, 160, 209 - 226
• Lateral habenula as a source of negative reward signals in dopamine neurons., Matsumoto M, Hikosaka, O, Nature, 2007
• Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate, Nakamura K, Hikosaka O, J Neurosci., 2006/12, 26(50), 12885 - 95
• Extended LATER model can account for trial-by-trial variability of both pre- and post-processes., Nakahara H, Nakamura K, Hikosaka O, Neural Netw. Oct, 2006/10, 19(8), 1027 - 1046
• Effects of explicit knowledge of workspace rotation in visuomotor sequence learning, Watanabe K, Ikeda H, Hikosaka O, Exp Brain Res, 2006/10, 174(4), 673 - 678
• Comparison of reward modulation in the frontal eye field and caudate of the macaque, Ding L, Hikosaka O, J Neurosci. 2006 Jun 21, 2006/06, 26(25), 6695 - 6703
• Role of dopamine in the primate caudate nucleus in reward modulation of saccades, Nakamura K, Hikosaka O, J Neurosci. May 17, 2006/05, 26(20), 5360 - 5369
• Basal ganglia orient eyes to reward, Hikosaka O, Nakamura K, Nakahara H, J Neurophysiol. Feb, 2006/02, 95(2), 567 - 584

解説

• Cortico-basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors. , Isoda M, Hikosaka O, Eur J Neurosci , 2011, 33:, 2058 - 2069
• Dopamine in motivational control: rewarding, aversive, and alerting. , Bromberg-Martin ES, Matsumoto M, Hikosaka O, Neuron , 2010, 68:, 815 - 834
• The habenula: from stress evasion to value-based decision-making. , Hikosaka O, Nat Rev Neurosci , 2010, 11:, 503 - 513
• Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms. , Hikosaka O, Isoda M, Trends Cogn Sci , 2010, 14: , 154 - 161
• Nature Reviews Neuroscience, 　, 10, 2008/12
• Habenula: crossroad between the basal ganglia and the limbic system. , Hikosaka O, Sesack SR, Lecourtier L, Shepard PD, J Neurosci , 2008, 28: , 11825 - 1182
• The DANA Foundation News, The DANA Foundation, The DANA Foundation News, 2008
• ScienceNews, 　, 　, 2008
• New insights on the subcortical representation of reward. , Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M, Curr Opin Neurobiol , 2008, 18: , 203 - 208

著書

• 「目と精神―彦坂興秀の課外授業」（神経心理学コレクション）, 彦坂興秀、河村満、山鳥重：共著, 医学書院, 2003/04
• Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration, Nomura Y, Fukuda H, Terao Y, Hikosaka O, Segawa M, Brain Dev 25 Suppl 1:S48-54, 2003
• Neural mechanisms for learning of sequential procedures. In: The Cognitive Neurosciiences pp.553-572, Hikosaka O, Sakai K, Nakahara H. LU X, Miychi S, Nakamura K, Rand MK(Gazzaniga MS, eds), Cambridge, MA:The MIT Press, 1999
• Learning of sequential procedures in monkeys. In: The Acquisition of Motor Behavior in Vertebrates, Hikosaka O, Miyachi S, Miyashita K, Rand MK(Bloedel JR, Ebner TJ, Wise SP, eds), Cambridge, MA: The MIT Press., 1996
• Procedural learning in monkeys - possible roles of the basal ganglia. In: Perception, Memory, and Emotion: Frontier in Neuroscience pp. 403-420, Hikosaka O, Miyachi S, Miyashita K, Rand MK, Karadi Z(Ono T, McNaughton BL, Molotchnikoff S, Rolls ET, Nishijo H, eds), Oxford, UK: Elsevier, 1996

国際会議

• Okihide Hikosaka, Parallel control of volition and skill by the basal ganglia , (Keynote Lecture) IBAGS-XI (11th Triennial meeting of the International Basal Ganglia Society) , Eilat, Israel, 2013/03/03-2013/03/07
• Okihide Hikosaka, Role of basal ganglia in valuation, memory, and skill , University of California, San Diego, San Diego, CA, 2013/02/12
• Okihide Hikosaka, Choosing valuable objects automatically – a basal ganglia mechanism Workshop 2, Cognitive Neuroscience Mathematical Biosciences Institute (MBI) , Columbus, Ohio , 2012/12/11
• Okihide Hikosaka, Basal ganglia mechanisms for choosing valuable objects automatically , University of Parma, Parma, Italy, 2012/11/16
• Okihide Hikosaka, Automatic valuation by the basal ganglia, ESF-FENS Conferences on The Dynamic Brain, The Neurobiology of Emotion , Stresa, Italy, 2012/11/13
• Okihide Hikosaka, Basal ganglia mechanisms for choosing valuable objects automatically , Champalimaud Neuroscience Programme (CNP), Lisbon, Portugalo, 2012/11/08
• Okihide Hikosaka, Long-term reward experiences bias eye movements: a role of the basal ganglia, David Robinson Lecture , Johns Hopkins University, School of Medicine, 2012/04/05
• Okihide Hikosaka, Choosing good objects – a basal ganglia mechanism, Inaugural Phillip A. Sharp Lecture in Neural Circuits McGovern Institute, MIT, 2012/03/01
• Okihide Hikosaka, Some issues in decision-making research, University of Texas, Austin, TX, 2011/12/13
• Okihide Hikosaka, Long-term reward experiences bias eye movements: a role of the basal ganglia , University of Texas, Austin, TX, 2011/12/12
• Okihide Hikosaka, Long-term object-reward memories in the basal ganglia underlying visuomotor habit , University of Minnesota, MN, 2011/10/14
• Okihide Hikosaka, How long-term reward experience influences behavior: a possible role of the posterior ganglia Keynote Lecture, Janelia Farm Conference: Neural Circuits of Decision-Making , Janelia Farm Research Campus, VA, 2011/03/06-2011/03/09
• Okihide Hikosaka, Subcortical mechanisms of motivational behavior, Carnegie Institution, Baltimore, MD, 2011/01/17
• Okihide Hikosaka, Motivational Neuronal Circuits for Value, Salience, and Information, Presidential Special Lecture, Society for Neuroscience, 40th Annual Meeting, San Diego, CA, 2010/11/14
• Okihide Hikosaka, Decision-making by cortico-basal ganglia networks , NIH Research Festival Symposia Session III: The Brain and the Construction of Complex Behaviors, 2010/10/06
• Okihide Hikosaka, Lateral habenula sends motivational information to the basal ganglia , The International Basal Ganglia Society, 10th Triennial Meeting , Long Branch, NJ, 2010/06/20-2010/06/24
• Okihide Hikosaka, Role of the lateral habenula in value-based decision-making, Symposium: The Lateral Habenula: Its Role in Behavior and Psychiatric Disorders, Cold Spring Harbor, NY, 2010/02/28-2010/03/03
• Okihide Hikosaka, Subcortical control of motivational behavior , RIKEN, BSI, 2010/01/26
• Okihide Hikosaka, Subcortical mechanisms of motivational behavior , New York University, 2009/12/07
• Okihide Hikosaka, Subcortical mechanisms of motivational behavior - Beyond dopamine neurons, University of Pennsylvania, 2009/11/23
• Okihide Hikosaka, Subcortical neurons representing motivational value and salience, Yale University, 2009/09/17
• Okihide Hikosaka, Rethinking dopamine neurons , Tamagawa University, 2009/08/04
• Okihide Hikosaka, Biasing, switching, and learning of behavior by the basal ganglia, Symposium: Multidisciplinary Approaches to Basal Ganglia Functions, International Union of Physiological Sciences 2009 , Kyoto, Japan, 2009/07/29
• Okihide Hikosaka, New concepts of dopamine neurons , Hokkaido University, 2009/07/21
• Okihide Hikosaka, Subcortical mechanisms of reward-based learning, Gordon Research Conferences: Neural Circuits & Plasticity, Salve Regina University, Newport, RI, 2009/06/07-2009/06/12
• Okihide Hikosaka, Motor skill learning and decision-making: cortico-basal ganglia mechanisms, Georgetown University, 2009/05/12
• Okihide Hikosaka, How the brain encodes reward, McGovern Institute (MIT) Symposium on “The Basal Ganglia in Health and Disease”, MIT, Boston, 2009/05/07
• Okihide Hikosaka, Subcortical networks for motivational decision making, Eye Movements and Vision: A Symposium in Honor of Fred Miles, Oxford University, 2009/04/01-2009/04/03
• Okihide Hikosaka, Neural mechanisms of motor skill learning, execution, and switching , NINDS, 2009/03/03
• Okihide Hikosaka, Role of the subcortical reward system in decision-making, Baylor College of Medicine, Houston, Texas, 2009/02/06
• Okihide Hikosaka, Multiple neural mechanisms of motor learning, automaticity, and switching, Netherlands Institute for Neuroscience (NIN) conference, Amsterdam, Netherlands, 2008/12/09-2008/12/12
• Okihide Hikosaka, Role of the Primate Lateral Habenula in Negative Motivational Control of Oculomotor Behavior, Symposium: “Habenula - Crossroad between the Basal Ganglia and the Limbic System”, Society for Neuroscience Annual Meeting, Washington DC, USA, 2008/11/19
• Okihide Hikosaka, Basal ganglia mechanisms of reward-based and instruction-based decision-making , University of Texas, Austin, 2008/10/06
• Okihide Hikosaka, Reward-based control of eye movements by the basal ganglia and surrounding structures, National Institute on Drug Abuse (NIDA), 2008/09/23
• Okihide Hikosaka, Motivational and cognitive control of behavior by the basal ganglia, Workshop on Mechanism of Brain and Mind, Sapporo, Japan, 2008/08/10
• Okihide Hikosaka, Neural mechanisms of reward-based and instruction-based decision-making, Columbia University, 2008/06/19
• Okihide Hikosaka, Integration of cognition and motivation in the basal ganglia and surrounding structures , Albert Einstein College of Medicine of Yeshiva University, 2008/04/23
• Okihide Hikosaka, Neural mechanisms of reward-oriented behavior: Beyond dopamine neurons, Harvard University, 2008/02/05

受賞

• Member, American Academy of Arts & Sciences, Okihide Hikosaka, 2011
• Tokizane Toshihiko Memorial Award , Hikosaka O., 1999

記事掲載／その他

• Nature Reviews Neuroscience 10, 2008/12
• The DANA Foundation News, 2008
• ScienceNews, 2008

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