Okihide Hikosaka

Affiliation	National Eye Institute, National Institutes of Health (NIH)
Position Title	Senior Investigator
Role	Neural mechanisms of decision making and emotion
Field of Specialization	neurophysiology
Research Keywords	saccadic eye movement, reward, motivation, switching, basal ganglia, superior colliculus, lateral habenula, pre-supplementary motor area
Professional Affiliation	Society for Neuroscience, The Society for the Neural Control of Movement

Articles

pyElectrode: An open-source tool using structural MRI for electrode positioning and neuron mapping. , Daye PM, Monosov I, Hikosaka O, Leopold DA, Optican LM , J Neurosci Methods , 2013, 213: , 123 - 131
The primate ventral pallidum encodes expected reward value and regulates motor action. , Tachibana Y, Hikosaka O, Neuron , 2012, 76: , 826 - 837
Robust representation of stable object values in the oculomotor basal ganglia. , Yasuda M, Yamamoto S, Hikosaka O, J Neurosci , 2012, 32: , 16917 - 16932
What and where information in the caudate tail guides saccades to visual objects. , Yamamoto S, Monosov IE, Yasuda M, Hikosaka, O, J Neurosci , 2012, 32: , 11005 - 11016
Regionally distinct processing of rewards and punishments by the primate ventromedial prefrontal cortex. , Monosov IE, Hikosaka O, J Neurosci , 2012, 32: , 10318 - 10330
Learning to represent reward structure: a key to adapting to complex environments. , Nakahara H, Hikosaka O , Neurosci Res , 2012, 74: , 177 - 183
Electrical Stimulation of the Primate Lateral Habenula Suppresses Saccadic Eye Movement through a Learning Mechanism. , Matsumoto M, Hikosaka O, PLoS One, 2011, 6:e26701
Lateral habenula neurons signal errors in the prediction of reward information. , Bromberg-Martin ES, Hikosaka O , Nat Neurosci , 2011, 14: , 1209 - 1216
Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. , Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O, J Neurosci , 2011, 31:, 11457 - 11471
Dopamine-mediated learning and switching in cortico-striatal circuit explain behavioral changes in reinforcement learning. , Hong S, Hikosaka O, Front Behav Neurosci , 2011, 5:, 15
Initiation and inhibitory control of saccades with the progression of Parkinson's disease - Changes in three major drives converging on the superior colliculus. , Terao Y, Fukuda H, Yugeta A, Hikosaka O, Nomura Y, Segawa M, Hanajima R, Tsuji S, Ugawa Y , Neuropsychologia , 2011, 49:, 1794 - 1806
Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons., Bromberg-Martin Ethan S, Matsumoto Masayuki, Hikosaka Okihide, Neuron, 2010, 67(1), 144 - 155
Multiple timescales of memory in lateral habenula and dopamine neurons. , Bromberg-Martin ES, Matsumoto M, Nakahara H, Hikosaka O, Neuron , 2010, 67:, 499 - 510
A pallidus-habenula-dopamine pathway signals inferred stimulus values. , Bromberg-Martin ES, Matsumoto M, Hong S, Hikosaka O, J Neurophysiol , 2010, 104:, 1068 - 1076
Coding of task reward value in the dorsal raphe nucleus. , Bromberg-Martin ES, Hikosaka O, Nakamura K, J Neurosci , 2010, 30: , 6262 - 6272
Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease. , Yugeta A, Terao Y, Fukuda H, Hikosaka O, Yokochi F, Okiyama R, Taniguchi M, Takahashi H, Hamada I, Hanajima R, Ugawa Y, Neurology , 2010, 74:, 743 - 748
Representation of negative motivational value in the primate lateral habenula, Matsumoto M, Hikosaka O, Nat Neurosci, 2009, 12, 77 - 84
Two types of dopamine neuron distinctly convey positive and negative motivational signals. , Matsumoto M, Hikosaka O, Nature , 2009, 459:, 837 - 841
Midbrain dopamine neurons signal preference for advance information about upcoming rewards. , Bromberg-Martin ES, Hikosaka O, Neuron , 2009, 63: , 119 - 126
Habenula: crossroad between the basal ganglia and the limbic system, Hikosaka O, Sesack SR, Lecourtier L, Shepard PD, J Neurosci , 2008, 28, 11825 - 11829
New insights on the subcortical representation of reward, Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M, Curr Opin Neurobiol , 2008, 18, 203 - 208
The globus pallidus sends reward-related signals to the lateral habenula, Hong S, Hikosaka O, Neuron, 2008, 60, 720 - 729
Combining Modalities with Different Latencies for Optimal Motor Control., Bissmarck F, Nakahara H, Doya K, Hikosaka O, J Cogn Neurosci, 2008, 20, 1966 - 1979
A neural correlate of motivational conflict in the superior colliculus of the macaque, Isoda M, Hikosaka O, J Neurophysiol , 2008, 100, 1332 - 1342
Brain mechanisms for switching from automatic to controlled eye movements, Hikosaka O, Isoda M, Prog Brain Res, 2008, 171, 375 - 382
Negative motivational control of saccadic eye movement by the lateral habenula, Matsumoto M, Hikosaka O, Prog Brain Res, 2008, 171, 399 - 402
Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus, Nakamura K, Matsumoto M, Hikosaka O, J Neurosci, 2008, 28, 5331 - 5343
Combining Modalities with Different Latencies for Optimal Motor Control. , Bissmarck F, Nakahara H, Doya K, Hikosaka O, J Cogn Neurosci , 2008, 20: , 1966 - 1979
Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement. , Isoda M, Hikosaka O, J Neurosci , 2008, 28: , 7209 - 7218
Switching from automatic to controlled action by monkey medial frontal cortex., Isoda M, Hikosaka O, Nat Neurosci, 2007/01, Jan 21
Temporal development of asymmetric reward-induced bias in macaques. , Ding L, Hikosaka O, J Neurophysiol, 2007/01, 97(1), 57 - 61
The role of the dorsal striatum in reward and decision-making, Balleine BW, Delgado MR, Hikosaka O, J Neurosci , 2007, 27, 8161 - 8165
Basal Ganglia Mechanisms of Reward-oriented Eye Movement, Hikosaka O, Ann N Y Acad Sci , 2007, 1104, 229 - 249
GABAergic output of the basal ganglia, Hikosaka O, Prog Brain Res, 2007, 160, 209 - 226
Lateral habenula as a source of negative reward signals in dopamine neurons., Matsumoto M, Hikosaka, O, Nature, 2007
Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate, Nakamura K, Hikosaka O, J Neurosci., 2006/12, 26(50), 12885 - 95
Extended LATER model can account for trial-by-trial variability of both pre- and post-processes., Nakahara H, Nakamura K, Hikosaka O, Neural Netw. Oct, 2006/10, 19(8), 1027 - 1046
Effects of explicit knowledge of workspace rotation in visuomotor sequence learning, Watanabe K, Ikeda H, Hikosaka O, Exp Brain Res, 2006/10, 174(4), 673 - 678
Comparison of reward modulation in the frontal eye field and caudate of the macaque, Ding L, Hikosaka O, J Neurosci. 2006 Jun 21, 2006/06, 26(25), 6695 - 6703
Role of dopamine in the primate caudate nucleus in reward modulation of saccades, Nakamura K, Hikosaka O, J Neurosci. May 17, 2006/05, 26(20), 5360 - 5369
Basal ganglia orient eyes to reward, Hikosaka O, Nakamura K, Nakahara H, J Neurophysiol. Feb, 2006/02, 95(2), 567 - 584

Reviews

Cortico-basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors. , Isoda M, Hikosaka O, Eur J Neurosci , 2011, 33:, 2058 - 2069
Dopamine in motivational control: rewarding, aversive, and alerting. , Bromberg-Martin ES, Matsumoto M, Hikosaka O, Neuron , 2010, 68:, 815 - 834
The habenula: from stress evasion to value-based decision-making. , Hikosaka O, Nat Rev Neurosci , 2010, 11:, 503 - 513
Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms. , Hikosaka O, Isoda M, Trends Cogn Sci , 2010, 14: , 154 - 161
Nature Reviews Neuroscience, 　, 10, 2008/12
Habenula: crossroad between the basal ganglia and the limbic system. , Hikosaka O, Sesack SR, Lecourtier L, Shepard PD, J Neurosci , 2008, 28: , 11825 - 1182
The DANA Foundation News, The DANA Foundation, The DANA Foundation News, 2008
ScienceNews, 　, 　, 2008
New insights on the subcortical representation of reward. , Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M, Curr Opin Neurobiol , 2008, 18: , 203 - 208

Books

Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration, Nomura Y, Fukuda H, Terao Y, Hikosaka O, Segawa M, Brain Dev 25 Suppl 1:S48-54, 2003
Neural mechanisms for learning of sequential procedures. In: The Cognitive Neurosciiences pp.553-572, Hikosaka O, Sakai K, Nakahara H. LU X, Miychi S, Nakamura K, Rand MK(Gazzaniga MS, eds), Cambridge, MA:The MIT Press, 1999
Learning of sequential procedures in monkeys. In: The Acquisition of Motor Behavior in Vertebrates, Hikosaka O, Miyachi S, Miyashita K, Rand MK(Bloedel JR, Ebner TJ, Wise SP, eds), Cambridge, MA: The MIT Press., 1996
Procedural learning in monkeys - possible roles of the basal ganglia. In: Perception, Memory, and Emotion: Frontier in Neuroscience pp. 403-420, Hikosaka O, Miyachi S, Miyashita K, Rand MK, Karadi Z(Ono T, McNaughton BL, Molotchnikoff S, Rolls ET, Nishijo H, eds), Oxford, UK: Elsevier, 1996

International Conferences

Okihide Hikosaka, Parallel control of volition and skill by the basal ganglia , (Keynote Lecture) IBAGS-XI (11th Triennial meeting of the International Basal Ganglia Society) , Eilat, Israel, 2013/03/03-2013/03/07
Okihide Hikosaka, Role of basal ganglia in valuation, memory, and skill , University of California, San Diego, San Diego, CA, 2013/02/12
Okihide Hikosaka, Choosing valuable objects automatically – a basal ganglia mechanism Workshop 2, Cognitive Neuroscience Mathematical Biosciences Institute (MBI) , Columbus, Ohio , 2012/12/11
Okihide Hikosaka, Basal ganglia mechanisms for choosing valuable objects automatically , University of Parma, Parma, Italy, 2012/11/16
Okihide Hikosaka, Automatic valuation by the basal ganglia, ESF-FENS Conferences on The Dynamic Brain, The Neurobiology of Emotion , Stresa, Italy, 2012/11/13
Okihide Hikosaka, Basal ganglia mechanisms for choosing valuable objects automatically , Champalimaud Neuroscience Programme (CNP), Lisbon, Portugalo, 2012/11/08
Okihide Hikosaka, Long-term reward experiences bias eye movements: a role of the basal ganglia, David Robinson Lecture , Johns Hopkins University, School of Medicine, 2012/04/05
Okihide Hikosaka, Choosing good objects – a basal ganglia mechanism, Inaugural Phillip A. Sharp Lecture in Neural Circuits McGovern Institute, MIT, 2012/03/01
Okihide Hikosaka, Some issues in decision-making research, University of Texas, Austin, TX, 2011/12/13
Okihide Hikosaka, Long-term reward experiences bias eye movements: a role of the basal ganglia , University of Texas, Austin, TX, 2011/12/12
Okihide Hikosaka, Long-term object-reward memories in the basal ganglia underlying visuomotor habit , University of Minnesota, MN, 2011/10/14
Okihide Hikosaka, How long-term reward experience influences behavior: a possible role of the posterior ganglia Keynote Lecture, Janelia Farm Conference: Neural Circuits of Decision-Making , Janelia Farm Research Campus, VA, 2011/03/06-2011/03/09
Okihide Hikosaka, Subcortical mechanisms of motivational behavior, Carnegie Institution, Baltimore, MD, 2011/01/17
Okihide Hikosaka, Motivational Neuronal Circuits for Value, Salience, and Information, Presidential Special Lecture, Society for Neuroscience, 40th Annual Meeting, San Diego, CA, 2010/11/14
Okihide Hikosaka, Decision-making by cortico-basal ganglia networks , NIH Research Festival Symposia Session III: The Brain and the Construction of Complex Behaviors, 2010/10/06
Okihide Hikosaka, Lateral habenula sends motivational information to the basal ganglia , The International Basal Ganglia Society, 10th Triennial Meeting , Long Branch, NJ, 2010/06/20-2010/06/24
Okihide Hikosaka, Role of the lateral habenula in value-based decision-making, Symposium: The Lateral Habenula: Its Role in Behavior and Psychiatric Disorders, Cold Spring Harbor, NY, 2010/02/28-2010/03/03
Okihide Hikosaka, Subcortical control of motivational behavior , RIKEN, BSI, 2010/01/26
Okihide Hikosaka, Subcortical mechanisms of motivational behavior , New York University, 2009/12/07
Okihide Hikosaka, Subcortical mechanisms of motivational behavior - Beyond dopamine neurons, University of Pennsylvania, 2009/11/23
Okihide Hikosaka, Subcortical neurons representing motivational value and salience, Yale University, 2009/09/17
Okihide Hikosaka, Rethinking dopamine neurons , Tamagawa University, 2009/08/04
Okihide Hikosaka, Biasing, switching, and learning of behavior by the basal ganglia, Symposium: Multidisciplinary Approaches to Basal Ganglia Functions, International Union of Physiological Sciences 2009 , Kyoto, Japan, 2009/07/29
Okihide Hikosaka, New concepts of dopamine neurons , Hokkaido University, 2009/07/21
Okihide Hikosaka, Subcortical mechanisms of reward-based learning, Gordon Research Conferences: Neural Circuits & Plasticity, Salve Regina University, Newport, RI, 2009/06/07-2009/06/12
Okihide Hikosaka, Motor skill learning and decision-making: cortico-basal ganglia mechanisms, Georgetown University, 2009/05/12
Okihide Hikosaka, How the brain encodes reward, McGovern Institute (MIT) Symposium on “The Basal Ganglia in Health and Disease”, MIT, Boston, 2009/05/07
Okihide Hikosaka, Subcortical networks for motivational decision making, Eye Movements and Vision: A Symposium in Honor of Fred Miles, Oxford University, 2009/04/01-2009/04/03
Okihide Hikosaka, Neural mechanisms of motor skill learning, execution, and switching , NINDS, 2009/03/03
Okihide Hikosaka, Role of the subcortical reward system in decision-making, Baylor College of Medicine, Houston, Texas, 2009/02/06
Okihide Hikosaka, Multiple neural mechanisms of motor learning, automaticity, and switching, Netherlands Institute for Neuroscience (NIN) conference, Amsterdam, Netherlands, 2008/12/09-2008/12/12
Okihide Hikosaka, Role of the Primate Lateral Habenula in Negative Motivational Control of Oculomotor Behavior, Symposium: “Habenula - Crossroad between the Basal Ganglia and the Limbic System”, Society for Neuroscience Annual Meeting, Washington DC, USA, 2008/11/19
Okihide Hikosaka, Basal ganglia mechanisms of reward-based and instruction-based decision-making , University of Texas, Austin, 2008/10/06
Okihide Hikosaka, Reward-based control of eye movements by the basal ganglia and surrounding structures, National Institute on Drug Abuse (NIDA), 2008/09/23
Okihide Hikosaka, Motivational and cognitive control of behavior by the basal ganglia, Workshop on Mechanism of Brain and Mind, Sapporo, Japan, 2008/08/10
Okihide Hikosaka, Neural mechanisms of reward-based and instruction-based decision-making, Columbia University, 2008/06/19
Okihide Hikosaka, Integration of cognition and motivation in the basal ganglia and surrounding structures , Albert Einstein College of Medicine of Yeshiva University, 2008/04/23
Okihide Hikosaka, Neural mechanisms of reward-oriented behavior: Beyond dopamine neurons, Harvard University, 2008/02/05

Awards

Member, American Academy of Arts & Sciences, Okihide Hikosaka, 2011
Tokizane Toshihiko Memorial Award , Hikosaka O., 1999

News / Others

Nature Reviews Neuroscience 10, 2008/12
The DANA Foundation News, 2008
ScienceNews, 2008

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